TP53 structure-function relationships in metastatic castrate-sensitive prostate cancer and the impact of APR-246 treatment.

Tung HoangPhilip SuteraTriet NguyenJinhee ChangShreya JagtapYang SongAmol C ShettyDipanwita D ChowdhuryAaron ChanFrancesca A CarrieriLara HathoutRonald EnnisSalma K JabbourRahul R ParikhJason MolitorisDaniel Y SongTheodore DeWeeseLuigi MarchionniLei RenAmit SawantNicole SimoneAudrey LafargueKim Van Der EeckenFred BunzPiet OstPhuoc T TranMatthew P Deek

Published in: The Prostate (2023)

DN TP53 mutations correlated with worse prognosis in prostate cancer patients and higher metastatic potential, which could be counteracted by APR-246 treatment suggesting a potential future therapeutic avenue.

Keyphrases

prostate cancer
squamous cell carcinoma
small cell lung cancer
radical prostatectomy
risk assessment
human health
replacement therapy
benign prostatic hyperplasia