Facile fabrication of water-dispersible nanocomposites based on hexa- peri -hexabenzocoronene and Fe 3 O 4 for dual mode imaging (fluorescent/MR) and drug delivery.
Meng-Meng SongHui-Hui XiangMeng-Yu FeiDa-Peng LuTong-Cui JiangYong-Qiang YuRui LiuYu-Xian ShenPublished in: RSC advances (2018)
The facile fabrication of multifunctional nanocomposites (Fe 3 O 4 /HBC@F127) consisting of superparamagnetic Fe 3 O 4 nanoparticles and fluorescent organic hexa- peri -hexabenzocoronene (HBC) molecules incorporated in block copolymer diacylphospholipid-polyethyleneglycol F127 have been demonstrated for dual mode imaging (fluorescent/MR) and drug delivery. The obtained nanocomposites were water-dispersible, stable and biocompatible, as confirmed by dynamic light scattering (DLS) and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Relativity measurements showed a T 2 relaxivity ( r 2 ) of 214.61 mM -1 s -1 , which may be used as T 2 -weighted MR imaging agents. In vitro imaging studies indicated that the nanocomposites had good MR and fluorescence imaging effects with low cytotoxicity. Besides, the developed nanocomposites could also be applied as drug delivery vehicles. Doxorubicin (DOX) loaded Fe 3 O 4 /HBC@F127 nanocomposites significantly inhibited the growth of human hepatoma cells (HepG2). These findings suggested that the facile synthesized multifunctional nanocomposites may be used as a platform for dual mode imaging (both MR and fluorescence) and drug delivery.
Keyphrases
- drug delivery
- reduced graphene oxide
- cancer therapy
- drug release
- visible light
- fluorescence imaging
- quantum dots
- high resolution
- contrast enhanced
- carbon nanotubes
- gold nanoparticles
- magnetic resonance
- high throughput
- endothelial cells
- photodynamic therapy
- induced apoptosis
- single molecule
- highly efficient
- ionic liquid
- tissue engineering
- energy transfer