First seizure in elderly patients: Need to treat? Evidence from a retrospective study.
Louise LinkaBenedikt MagnusNabard FaizLena HabermehlPanagiota-Eleni TsalouchidouFelix ZahnertLeona MoellerKristina KrauseSusanne KnakeKatja MenzlerPublished in: Neurological research and practice (2024)
The present data show a strong protective effect of ASM on seizure recurrence in patients above the age of 60, even in the absence of pathologic neuroimaging or EEG results needed for the diagnosis of epilepsy. Treatment with ASM therefore seems beneficial for reducing the recurrence risk in elderly patients. The lack of a significant association between seizure recurrence and epileptogenic lesions might be related to other confounding factors like encephalopathy, subcortical arteriosclerotic encephalopathy, neurodegenerative diseases or brain atrophy.
Keyphrases
- temporal lobe epilepsy
- end stage renal disease
- free survival
- early onset
- resting state
- white matter
- newly diagnosed
- functional connectivity
- peritoneal dialysis
- prognostic factors
- working memory
- squamous cell carcinoma
- big data
- combination therapy
- cerebral ischemia
- blood brain barrier
- brain injury
- subarachnoid hemorrhage
- deep learning
- drug induced