A Computational Approach: The Functional Effects of Thyroid Peroxidase Variants in Thyroid Cancer and Genetic Disorders.

Adebiyi SobitanBrhan GebremedhinQiaobin YaoGuiqin XieXinbin GuJiang LiShaolei Teng

Published in: JCO clinical cancer informatics (2024)

These findings highlight the impact of these specific mutations on TPO stability, linking them to thyroid cancer and other genetic thyroid-related disorders. Our results show that computational mutagenesis of proteins provides a quick insight into rare mutations causing Mendelian disorders and cancers in humans.

Keyphrases

copy number
genome wide
crispr cas
hydrogen peroxide
dna methylation
gene expression
nitric oxide
young adults