Schisandrin protects against ulcerative colitis by inhibiting the SGK1/NLRP3 signaling pathway and reshaping gut microbiota in mice.

Xiaohu WangChaozhuang ShenXingwen WangJin TangZijing WuYunzhe HuangWenxin ShaoKuo GengHaitang XieZhichen Pu

Published in: Chinese medicine (2023)

It seems that there is a close relationship between the SCH mechanism and the regulation of SGK1/NLRP3 pathway and the restoration of GM balance. Therefore, it can be concluded that SCH could be a potential drug for the treatment of UC.

Keyphrases

signaling pathway
ulcerative colitis
pi k akt
nlrp inflammasome
epithelial mesenchymal transition
induced apoptosis
type diabetes
emergency department
combination therapy
risk assessment
drug induced
replacement therapy
human health
smoking cessation