Up-regulation of resident chromosomal fosB gene expression: a novel mechanism of acquired fosfomycin resistance in MRSA.

Noemi AiezzaAlberto AntonelliMarco CoppiVincenzo di PilatoTommaso GianiGian Maria Rossolini

Published in: The Journal of antimicrobial chemotherapy (2023)

This study showed that some S. aureus clonal lineages carry a resident chromosomal fosB gene and can evolve to fosfomycin resistance by overexpression of this gene.

Keyphrases

copy number
gene expression
genome wide
patient safety
dna methylation
genome wide identification
urinary tract infection
quality improvement
methicillin resistant staphylococcus aureus
staphylococcus aureus
transcription factor
gram negative
cell proliferation
emergency medicine