Wnt antagonist secreted frizzled-related protein I (sFRP1) may be involved in the osteogenic differentiation of periodontal ligament cells in chronic apical periodontitis.

F YangDing-Ming HuangL XuW XuX YiX ZhouL YeLan Zhang

Published in: International endodontic journal (2021)

Wnt antagonist sFRP1 was involved in the osteogenic differentiation of hPDLCs under inflammation. Modulation of the Wnt/β-catenin signalling pathway through the inhibition of sFRP1 may offer a new perspective on the treatment of chronic apical periodontitis.

Keyphrases

cell proliferation
stem cells
induced apoptosis
oxidative stress
cell cycle arrest
epithelial mesenchymal transition
endoplasmic reticulum stress
pi k akt
combination therapy