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Synthetic Lethality Beyond BRCA: A Phase I Study of Rucaparib and Irinotecan in Metastatic Solid Tumors With Homologous Recombination-Deficiency Mutations Beyond BRCA1/2.

Erica S TsangMallika S DhawanRomain PacaudScott ThomasJennifer GrabowskyLauren WilchSilpa KaripineniRobin Kate KelleyAndrew H KoEric CollissonJocelyn S ChapmanStefanie UedaEmily K BergslandPamela Munster
Published in: JCO precision oncology (2024)
-mutated cancers despite progression on previous platinum.
Keyphrases
  • dna repair
  • dna damage
  • squamous cell carcinoma
  • small cell lung cancer
  • breast cancer risk