Sequential Targeting of Retinoblastoma and DNA Synthesis Pathways Is a Therapeutic Strategy for Sarcomas That Can Be Monitored in Real Time.
Tuyen Duong Thanh NguyenYang WangTuyen N BuiRossana LazcanoDavis R IngramMin YiVarshini VakulabharanamLinjie LuoMarc A PinaCansu KarakasMi LiNicole M KettnerNeeta SomaiahPeter J HoughtonOsama MawlawiAlexander J F LazarKelly K HuntKhandan KeyomarsiPublished in: Cancer research (2023)
An innovative sequential therapeutic strategy targeting Rb, followed by treatment with agents that perturb DNA synthesis pathways, results in synergistic killing of Rb-positive sarcomas that can be noninvasively monitored.