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Ponatinib Drives Cardiotoxicity by S100A8/A9-NLRP3-IL-1β Mediated Inflammation.

Sultan TousifAnand Prakash SinghPrachi UmbarkarCristi GalindoNicholas D WheelerAngelica Toro CoraQinkun ZhangSumanth D PrabhuHind Lal
Published in: Circulation research (2023)
Taken together, these findings uncover a novel mechanism of ponatinib-induced cardiac inflammation leading to cardiac dysfunction. From a translational perspective, our results provide critical preclinical data and rationale for a clinical investigation into immunosuppressive interventions for managing ponatinib-induced cardiotoxicity.
Keyphrases
  • oxidative stress
  • diabetic rats
  • high glucose
  • left ventricular
  • chronic myeloid leukemia
  • stem cells
  • endothelial cells
  • cell therapy
  • atrial fibrillation
  • deep learning
  • nlrp inflammasome