TRPM2 mediates distruption of autophagy machinery and correlates with the grade level in prostate cancer.

Ahmet TektemurSeda OzaydinEbru Etem OnalanNalan KayaTuncay Kulogluİbrahim Hanifi OzercanSuat TekinHalit Mohammed Elyas

Published in: Journal of cancer research and clinical oncology (2019)

We showed that the autophagy-TRPM2 association may take place in the molecular basis of PCa and accordingly this connection may be targeted as a new therapeutic approach in PCa.

Keyphrases

prostate cancer
cell death
endoplasmic reticulum stress
signaling pathway
oxidative stress
radical prostatectomy
cancer therapy
drug delivery