Elevated histone H3 acetylation is associated with genes involved in T lymphocyte activation and glutamate decarboxylase antibody production in patients with type 1 diabetes.
Yanfei WangCan HouJonathan WislerKanhaiya SinghChao WuZhiguo XieQianjin LuZhiguang ZhouPublished in: Journal of diabetes investigation (2018)
The present study generates a genome-wide histone acetylation profile specific to CD4+ T lymphocytes in type 1 diabetes patients who are glutamic acid decarboxylase antibody-positive, which is instrumental in improving our understanding of the epigenetic involvement in autoimmune diabetes.
Keyphrases
- type diabetes
- dna methylation
- genome wide
- end stage renal disease
- cardiovascular disease
- glycemic control
- ejection fraction
- newly diagnosed
- chronic kidney disease
- multiple sclerosis
- gene expression
- prognostic factors
- insulin resistance
- metabolic syndrome
- histone deacetylase
- adipose tissue
- drug induced
- patient reported