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Synthesis of N-Biheteroarenes via Acceptorless Dehydrogenative Coupling of Benzocyclic Amines with Indole Derivatives.

Xiuwen ChenYibiao LiLu ChenZhongzhi ZhuBin LiYubing HuangMin Zhang
Published in: The Journal of organic chemistry (2019)
Here, via a strategy of in situ capture of partially dehydrogenated cyclic amine motifs, we present an acceptorless dehydrogenative coupling of benzocyclic amines with indole derivatives that enables to access various quinoline-indole linked N-biheteroarenes in an efficient manner. The catalytic transformation is characteristic of operational simplicity, a readily available catalyst system, good substrate and functional compatibility, mild conditions, high atom efficiency, and no need for oxidant and halogenated coupling agents.
Keyphrases
  • room temperature
  • electron transfer
  • ionic liquid
  • molecular dynamics
  • molecular docking
  • metal organic framework
  • amino acid