Reduction of Cardiac Fibrosis by Interference With YAP-Dependent Transactivation.
Gloria GaroffoloManuel CasaburoFrancesco AmadeoMassimo SalviGiacomo BernavaLuca PiacentiniIsotta ChimentiGermana ZaccagniniGesmi MilcovichEstella ZuccoloMarco AgrifoglioSara RagazziniOtgon BaasansurenClaudia CozzolinoMattia ChiesaSilvia FerrariDario CarbonaroRosaria SantoroMartina ManzoniLoredana CasalisAngela RaucciFilippo MolinariLorenzo MenicantiFrancesca PaganoToshiro OhashiFabio MartelliDiana MassaiGualtiero Ivanoe ColomboElisa MessinaUmberto MorbiducciMaurizio PescePublished in: Circulation research (2022)
Our study indicates that preventing molecular translation of mechanical cues in cardiac stromal cells reduces the impact of cardiac maladaptive remodeling with a positive effect on fibrosis.
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