Estimating copy number to determine BRCA2 deletion status and to expect prognosis in localized prostate cancer.

Takuhisa NukayaMakoto SumitomoEiji SugiharaMayu TakedaSachio NoharaShigeki TanishimaMasashi TakenakaKenji ZennamiKiyoshi TakaharaRyoichi ShirokiHideyuki Saya

Published in: Cancer medicine (2023)

Our results suggest that a decrease in BRCA2 CN may be used as a biomarker for predicting recurrence after surgery in localized PC. Early screening for somatic alterations in BRCA2 using NGS may help to broadly predict the risk of PC progression.

Keyphrases

copy number
mitochondrial dna
prostate cancer
genome wide
breast cancer risk
dna methylation
radical prostatectomy
lymph node metastasis
squamous cell carcinoma
free survival