5,7,3',4'-Tetramethoxyflavone suppresses TGF-β1-induced activation of murine fibroblasts in vitro and ameliorates bleomycin-induced pulmonary fibrosis in mice.
Wen-Chien ChengPei Ying ChenXiang ZhangYu-Kang ChangKok-Tong TanTim C C Lin
Published in: Immunopharmacology and immunotoxicology (2024)
These findings suggest that TMF has the potential to effectively inhibit myofibroblast activation and could be a promising treatment for PF. TMF achieves this inhibitory effect by targeting TGF-β1/Smad and non-Smad pathways.