Impact of cerebral blood flow and amyloid load on SUVR bias.
Fiona HeemanMaqsood M YaqubJanine HendriksBart N M van BerckelLyduine E CollijKatherine R GrayRichard ManberRobin WolzValentina GaribottoCatriona WimberleyCraig W RitchieFrederik BarkhofJuan-Domingo GispertDavid Vállez GarcíaIsadora Lopes AlvesAdriaan A Lammertsmanull nullPublished in: EJNMMI research (2022)
The present findings demonstrate that bias in SUVR relative to DVR is strongly related to underlying Aβ burden. Furthermore, in a cohort consisting mainly of cognitively unimpaired individuals, the effect of relative CBF on bias in SUVR appears limited. EudraCT Number: 2018-002277-22, registered on: 25-06-2018.