Maternal Dietary Glycemic Index and Glycemic Load in Pregnancy and Offspring Cord Blood DNA Methylation.
Leanne K KüpersSílvia Fernández-BarrésGiulia MancanoLaura JohnsonRaffael OttJesus VioqueMarco ColomboKathrin LandgrafElmar W TobiAntje KörnerRomy GaillardJeanne H M de VriesVincent W V JaddoeMartine VrijheidGemma C SharpJanine F FelixPublished in: Diabetes care (2022)
We observed multiple associations of maternal glycemic index and load during pregnancy with cord blood DNA methylation, mostly in mothers with overweight/obesity; some of these CpGs were associated with gene expression. Additional studies are required to further explore functionality, uncover causality, and study pathways to offspring health.
Keyphrases
- cord blood
- dna methylation
- gene expression
- type diabetes
- pregnancy outcomes
- birth weight
- weight gain
- genome wide
- weight loss
- high fat diet
- glycemic control
- insulin resistance
- healthcare
- public health
- metabolic syndrome
- copy number
- mental health
- physical activity
- pregnant women
- health information
- emergency department
- climate change
- gestational age
- health promotion
- case control
- adverse drug
- social media