CCL5-armed oncolytic virus augments CCR5-engineered NK cell infiltration and antitumor efficiency.

Feng LiYuqiao ShengWeizhou HouPadma SampathDaniel ByrdStephen ThorneYi Zhang

Published in: Journal for immunotherapy of cancer (2021)

Enhancement of matched chemokines and chemokine receptors is a promising method of increasing NK cell homing and therapeutic effects. Oncolytic vaccinia viruses that express specific chemokines can synergistically augment the efficacies of NK cell-based therapy.

Keyphrases

nk cells
regulatory t cells
liver injury
immune response
bone marrow