Hypertensive target organ damage is better associated with central than brachial blood pressure: The Northern Shanghai Study.
Chen ChiXuejing YuRanshaka AuckleYuyan LuXimin FanShikai YuJing XiongBin BaiJiadela TeliewubaiYiwu ZhouHongwei JiJue LiYi ZhangYawei XuPublished in: Journal of clinical hypertension (Greenwich, Conn.) (2017)
To compare central and brachial blood pressure (BP) in the association of target organ damage (TOD) in a community-based elderly population, 1599 (aged 71.4 ± 6.1 years) participants in northern Shanghai were recruited. TOD included left ventricular hypertrophy (n = 1556), left ventricular diastolic dysfunction (n = 1524), carotid plaque (n = 1558), arteriosclerosis (n = 1485), and microalbuminuria (n = 1516). Both central and brachial BP significantly correlated with TOD. In full-model regression, central BP was significantly associated with all TOD (P ≤ .04), whereas brachial BP was only significantly associated with left ventricular hypertrophy and arteriosclerosis (P ≤ .01). Similarly, in stepwise regression, central BP was significantly associated with left ventricular hypertrophy, left ventricular diastolic dysfunction, arteriosclerosis, and microalbuminuria (P ≤ .04), while brachial BP was not associated with any TOD. Receiver operating characteristic analyses indicated that central BP identified arteriosclerosis and microalbuminuria better than brachial BP (P ≤ .01). In conclusion, central BP showed superiority over brachial BP in the association of hypertensive TOD in a community-based elderly population.
Keyphrases
- left ventricular
- blood pressure
- heart failure
- hypertrophic cardiomyopathy
- acute myocardial infarction
- cardiac resynchronization therapy
- aortic stenosis
- mitral valve
- oxidative stress
- peripheral artery disease
- left atrial
- type diabetes
- heart rate
- acute coronary syndrome
- metabolic syndrome
- ejection fraction
- middle aged
- community dwelling