Human rhinoviruses enter and induce proliferation of B lymphocytes.
Alar AabO WirzW van de VeenS SöllnerB StanicB RückertJ AniscenkoM R EdwardsS L JohnstonN G PapadopoulosA RebaneC A AkdisM AkdisPublished in: Allergy (2016)
Our results demonstrate for the first time that HRVs enter and form viral replication centers in B lymphocytes and induce the proliferation of B cells. Newly formed virions have the capacity to infect other cells (HeLa). These findings indicate that the regulation of human rhinovirus-induced B-cell responses could be a novel approach to develop therapeutics to treat the virus-induced exacerbation of asthma.
Keyphrases
- endothelial cells
- high glucose
- chronic obstructive pulmonary disease
- diabetic rats
- signaling pathway
- cell cycle arrest
- induced pluripotent stem cells
- induced apoptosis
- peripheral blood
- sars cov
- drug induced
- intensive care unit
- lung function
- air pollution
- pi k akt
- endoplasmic reticulum stress
- extracorporeal membrane oxygenation