Efficacy of ceftazidime/avibactam in various combinations for the treatment of experimental osteomyelitis in rabbits caused by OXA-48-/ESBL-producing Escherichia coli.

Benjamin DavidoAnne-Claude CrémieuxIsabelle VaugierPierre De TruchisKamel HamamiFrédéric LaurentAzzam Saleh-Mghir

Published in: The Journal of antimicrobial chemotherapy (2023)

In our model of E. coli OXA-48/ESBL osteomyelitis, ceftazidime/avibactam in combination was more effective than any single therapy, whatever the companion drug used (gentamicin or colistin or fosfomycin).

Keyphrases

klebsiella pneumoniae
escherichia coli
gram negative
multidrug resistant
acinetobacter baumannii
drug resistant
biofilm formation
stem cells
cystic fibrosis
drug induced