Circulating Levels of Calcitonin Gene-Related Peptide Are Lower in COVID-19 Patients.

Laura Ochoa-Callejero Josune García-SanmartínPablo Villoslada-BlancoMaría ÍñiguezPatricia Pérez-MatuteElisabet PujadasMary E FowkesRachel BrodyJosé Antonio Oteo Alfredo Martínez

Published in: Journal of the Endocrine Society (2021)

The lower levels of CGRP should negatively impact the respiratory physiology of COVID-19 patients due to vasoconstriction, improper angiogenesis, less epithelial repair, and faulty immune response. Therefore, restoring CGRP levels in these patients may represent a novel therapeutic approach for COVID-19.

Keyphrases

sars cov
immune response
end stage renal disease
coronavirus disease
ejection fraction
newly diagnosed
endothelial cells
prognostic factors
patient reported outcomes
transcription factor
inflammatory response
wound healing
respiratory tract