Interferon gamma regulates a complex pro-survival signal network in chronic lymphocytic leukemia.

Yixiang ChenXiaoya ShaoHaiping YangLeiying RenYing CuiWenlu ZhangSalvador MacipXueqiong Meng

Published in: European journal of haematology (2022)

Our data demonstrate that IFN-γ regulates a complex pro-survival signal network in CLL through JAK1/2-STAT3, which provides a rational explanation for IFN-γ promoting CLL cells survival and drug resistance.

Keyphrases

chronic lymphocytic leukemia
dendritic cells
free survival
immune response
induced apoptosis
anti inflammatory
big data
electronic health record
machine learning
oxidative stress
signaling pathway
cell death
network analysis