Hydrogen gas with extracorporeal cardiopulmonary resuscitation improves survival after prolonged cardiac arrest in rats.
Tai YinLance B BeckerRishabh C ChoudharyRyosuke TakegawaMuhammad ShoaibKoichiro ShinozakiYusuke EndoKoichiro HommaDaniel M RolstonShuhei EguchiTadashi AriyoshiAsami MatsumotoKentaro OkaMotomichi TakahashiTomoaki AokiSantiago J MiyaraMitsuaki NishikimiJunichi SasakiJunhwan KimErnesto P MolmentiKei HayashidaPublished in: Journal of translational medicine (2021)
H2 therapy improved mortality in highly lethal CA rats rescued by ECPR and helped recover brain electrical activity. The underlying mechanism might be linked to protective effects against endothelial damage. Further studies are warranted to elucidate the mechanisms responsible for the beneficial effects of H2 on ischemia-reperfusion injury in critically ill patients who require ECMO support.
Keyphrases
- cardiopulmonary resuscitation
- cardiac arrest
- extracorporeal membrane oxygenation
- acute respiratory distress syndrome
- resting state
- risk factors
- white matter
- oxidative stress
- endothelial cells
- room temperature
- cardiovascular disease
- type diabetes
- intensive care unit
- respiratory failure
- functional connectivity
- coronary artery disease
- bone marrow
- ionic liquid