Clustered protocadherins methylation alterations in cancer.

Ana Florencia Vega-BenedettiEleonora LoiLoredana MoiSylvain BloisAntonio FaddaManila AntonelliAntonella ArcellaManuela BadialiFelice GiangasperoIsabella MorraAmedeo ColumbanoAngelo RestivoLuigi ZorcoloViviana GismondiLiliana VarescoSara Erika BellomoSilvia GiordanoMatteo CanaleAndrea Casadei-GardiniLuca FaloppiMarco PuzzoniMario ScartozziPina ZiranuGiuseppina CabrasPierluigi CoccoMaria Grazia EnnasGiannina SattaMariagrazia ZuccaDaniele CanzioPatrizia Zavattari

Published in: Clinical epigenetics (2019)

Our study highlighted a strong alteration of the clustered PCDHs methylation pattern in the analysed solid cancers and suggested these methylation aberrations in the CpG islands associated with PCDH genes as powerful diagnostic biomarkers.

Keyphrases

genome wide
dna methylation
copy number
papillary thyroid
gene expression
squamous cell carcinoma
childhood cancer
transcription factor
genome wide analysis