Obeticholic acid treatment ameliorates the cardiac dysfunction in NASH mice.

Szu-Yu LiuChia-Chang Huang Ying-Ying YangShiang-Fen HuangTzung-Yan LeeTzu-Hao LiMing-Chih HouHan-Chieh Lin

Published in: PloS one (2022)

Chronic FXR activation with OCA is a potential strategy for activating IL-10/IL-10R signalling, reversing cardiac regulatory T cell dysfunction, and improving inflammasome-mediated NASH-related cardiac dysfunction.

Keyphrases

left ventricular
oxidative stress
signaling pathway
transcription factor
heart failure
mouse model
drug induced
skeletal muscle
wild type