Obligatory role of endoplasmic reticulum in brain FDG uptake.

Vanessa CossuCecilia MariniPatrizia PiccioliAnna RocchiSilvia BrunoAnna Maria OrengoLaura EmioniteMatteo BaucknehtFederica GrilloSelene CapitanioEnrica BalzaNikola YosifovPatrizia CastellaniGiacomo CavigliaIsabella PanfoliSilvia MorbelliSilvia RaveraFabio BenfenatiGianmario Sambuceti

Published in: European journal of nuclear medicine and molecular imaging (2019)

The activity of the reticular enzyme H6PD profoundly contributes to brain 18F-FDG uptake. These data challenge the current dogma linking 2DG/FDG uptake to the glycolytic rate and introduce a new model to explain the link between 18-FDG uptake and neuronal activity.

Keyphrases

pet ct
pet imaging
positron emission tomography
endoplasmic reticulum
white matter
resting state
cerebral ischemia
computed tomography
functional connectivity
multiple sclerosis
subarachnoid hemorrhage