A common IGF1R gene variant predicts later life breast cancer risk in women with preeclampsia.

Mark J Powell Sophia Fuller Erica P Gunderson Christopher C Benz

Published in: Breast cancer research and treatment (2022)

This retrospective cohort study found that women with preeclampsia who carry a T allele of IGF1R rs2016347 had a reduced future risk of developing HR+ breast cancer, and a reduced but not statistically significant decreased risk of non-breast cancers suggesting a possible role for the IGF-1 axis in the development of cancer in these women.

Keyphrases

breast cancer risk
pi k akt
early onset
binding protein
pregnancy outcomes
growth hormone
papillary thyroid
polycystic ovary syndrome
genome wide
signaling pathway
current status
gene expression
type diabetes
cell proliferation
insulin resistance