Combatting joint pain and inflammation by dual inhibition of monoacylglycerol lipase and cyclooxygenase-2 in a rat model of osteoarthritis.

Published in: Arthritis research & therapy (2020)

Combination therapy of KML29 plus CXB reduced joint pain and inflammation. Thus, dual inhibition of MAGL and cyclooxygenase-2 pathways could be a useful approach to alleviate joint inflammation and pain in OA joints.

Keyphrases

chronic pain
combination therapy
oxidative stress
pain management
neuropathic pain
knee osteoarthritis
rheumatoid arthritis
nitric oxide
postoperative pain
spinal cord
spinal cord injury