PTEN deficiency potentiates HBV-associated liver cancer development through augmented GP73/GOLM1.

Fuqiang HuangJing GuoNa ZhaoMengjie HouXiaochen GaiShuhui YangPei CaiYanan WangQian MaQi ZhaoLi LiHuayu YangYanling JingDi JinZhongdong HuXiaojun ZhaHongyang WangYilei MaoFangming LiuHongbing Zhang

Published in: Journal of translational medicine (2024)

This mixed HCC-ICC mouse model mimics liver cancer patients harboring HBV infection and PTEN/AKT signaling pathway alteration. Targeting GP73 is a promising therapeutic strategy for cancer patients with HBV infection and PTEN alteration.

Keyphrases

pi k akt
signaling pathway
hepatitis b virus
cell proliferation
liver failure
mouse model
papillary thyroid
induced apoptosis
epithelial mesenchymal transition
young adults
smoking cessation