Presence of crown-like structures in breast adipose tissue; differences between healthy controls, BRCA1/2 gene mutation carriers and breast cancer patients.
Mieke C ZwagerIris Holt-KeddeHetty Timmer-BosschaGeertruida H de BockPaul M N WerkerCarolien P SchröderBert van der VegtMarlous ArjaansPublished in: Breast cancer research and treatment (2023)
In conclusion, CLS were more frequently present in breast adipose tissue of breast cancer patients compared to BRCA1/2 gene mutation carriers and healthy controls. Furthermore, our study provides evidence of the association between obesity and presence of CLS. The prognostic significance and impact on clinical outcome of differences in CLS numbers should be further assessed in prospective studies.