Association between ustekinumab therapy and changes in specific anti-microbial response, serum biomarkers, and microbiota composition in patients with IBD: A pilot study.

Filip RobDagmar SchierovaZuzana StehlikovaJakub KreisingerRadka RoubalovaStepan CoufalMartin MihulaZuzana JackovaMiloslav KverkaTomas ThonKlara KostovcikovaLukas BajerPavel DrastichJana Tresnak HercogovaMichaela NovakovaMartin KolarMartin VasatkoMilan LukasHelena Tlaskalova-HogenovaZuzana Jiraskova Zakostelska

Published in: PloS one (2022)

In this preliminary study, we provide a unique overview of the longitudinal monitoring of fecal and skin microbial profiles as well as various serum biomarkers and humoral and cellular response to gut commensals in a small cohort of patients with IBD on ustekinumab therapy.

Keyphrases

microbial community
immune response
soft tissue
cell therapy
bone marrow
replacement therapy