Neurons contribute to pathology in a mouse model of Krabbe disease in a cell-autonomous manner.
Pedro BritesMonica Mendes SousaPublished in: PLoS biology (2022)
In this issue of PLOS Biology, Kreher and colleagues show in a mouse model that in vivo, neurons and not only myelinating glia are primary effectors of disease progression in Krabbe disease. The neuron-specific model generated allows the unprecedented capacity to investigate the neuronal autonomous component of this disorder.