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Neurons contribute to pathology in a mouse model of Krabbe disease in a cell-autonomous manner.

Pedro BritesMonica Mendes Sousa
Published in: PLoS biology (2022)
In this issue of PLOS Biology, Kreher and colleagues show in a mouse model that in vivo, neurons and not only myelinating glia are primary effectors of disease progression in Krabbe disease. The neuron-specific model generated allows the unprecedented capacity to investigate the neuronal autonomous component of this disorder.
Keyphrases
  • mouse model
  • spinal cord
  • single cell
  • cell therapy
  • spinal cord injury
  • mesenchymal stem cells
  • brain injury