Cocaine Effects on Reproductive Behavior and Fertility: An Overview.
Luigi RosatiTeresa ChianeseAldo MileoMaria De FalcoAnna CapaldoPublished in: Veterinary sciences (2023)
Cocaine is one of the most widely used drugs that, due to its molecular properties, causes various behavioral alterations, including sexual behavior. In vivo and in vitro studies conducted mainly in mammals have shown various disorders of sexual activity and morpho-functional dysfunctions of the gonads in both sexes. Although the modalities are still unclear, cocaine has been shown to alter the cell cycle, induce apoptosis, and alter sperm motility. In females, this drug alters the formation of the meiotic spindle as well as may obstruct the ovulation mechanism of mature oocytes. The data provided in this review, in addition to reviewing the current literature on the main effects of cocaine on spermatogenesis and oogenesis mainly in mammals, will hopefully provide a basic overview that may help and support further future studies on the molecular interaction of cocaine and its metabolites with germ cells.
Keyphrases
- cell cycle
- cell cycle arrest
- prefrontal cortex
- induced apoptosis
- cell proliferation
- oxidative stress
- systematic review
- endoplasmic reticulum stress
- cell death
- mental health
- ms ms
- case control
- emergency department
- type diabetes
- machine learning
- escherichia coli
- adipose tissue
- big data
- current status
- staphylococcus aureus
- candida albicans