Neurodegenerative biomarkers outperform neuroinflammatory biomarkers in amyotrophic lateral sclerosis.

Ulf KläppeStefan SennfältAnikó LovikAnja FinnUlrika BofaisalHenrik ZetterbergKaj BlennowFredrik PiehlIvan KmezicRayomand PressKristin SamuelssonAnna MånbergFang FangCaroline Ingre

Published in: Amyotrophic lateral sclerosis & frontotemporal degeneration (2023)

Biomarkers of neuroaxonal degeneration displayed better diagnostic and prognostic value compared with neuroinflammatory biomarkers. However, in contrast to spinal patients, in bulbar patients neurofilaments and CHIT1 performed worse at predicting survival and seemed to increase over time.

Keyphrases

end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
computed tomography
spinal cord injury