The histone acetyltransferase hMOF promotes vascular invasion in hepatocellular carcinoma.

Nicolas PotéJérôme CrosSamira LaouiremJérôme RaffenneMagda NegrãoMiguel AlbuquerquePierre BedossaMiguel Godinho FerreiraSlimane Ait Si AliRita FiorValérie Paradis

Published in: Liver international : official journal of the International Association for the Study of the Liver (2020)

Altogether, these results underpin a critical role for hMOF in vascular invasion in HCC, via transcription activation of key genes involved in this process. These data confirm the major role of epigenetic alterations in HCC progression, and pave the way for future therapies targeting hMOF in HCC.

Keyphrases

cell migration
dna methylation
gene expression
electronic health record
transcription factor
current status
big data
cancer therapy
data analysis
artificial intelligence