Laboratory approach for vaccine-induced thrombotic thrombocytopenia diagnosis in the Netherlands.
Romy T MeierLeendert PorcelijnSuzanne Hofstede-van EgmondYvonne M C HenskensJonathan M CoutinhoMarieke J H A KruipAn K StroobantsJaap J ZwagingaJohanna G van der BomC Ellen Van Der SchootMasja De HaasRick KapurPublished in: Vox sanguinis (2024)
Our study shows that only a small proportion of clinically suspected VITT patients with thrombocytopenia and thrombosis have anti-PF4-inducing, FcɣRIIa-dependent platelet activation, suggesting an HIT-like pathophysiology. This leaves the possibility for the presence of another type of pathophysiology ('non-HIT like') leading to VITT. More research on pathophysiology is warranted to improve the diagnostic algorithm and to identify novel therapeutic and preventive strategies.