RACGAP1 drives proliferation, migration and invasion and suppresses autophagy of gastric cancer cells via inhibiting SIRT1/Mfn2.

Tingting YanGuangxin LuRui ShangJunhua HuChaobei ZhuLingli Jin

Published in: Physiology international (2024)

RACGAP1 was overexpressed in gastric cancer. RACGAP1 potentiated aggressive behaviors of gastric cancer, and suppressed cell apoptosis and autophagy via modulating SIRT1/Mfn2. RACGAP1 may be a valuable target in the treatment of gastric cancer.

Keyphrases

signaling pathway
oxidative stress
cell death
endoplasmic reticulum stress
ischemia reperfusion injury
smoking cessation