Pharmacological modulation of Kv1.3 potassium channel selectively triggers pathological B lymphocyte apoptosis in vivo in a genetic CLL model.
Filippo SeverinAndrea UrbaniTatiana VaranitaMagdalena BachmannMichele AzzoliniVeronica MartiniMarco PizziAngelo Paolo Dei TosFederica FrezzatoAndrea MattareiPaolo GhiaMaria Teresa Sabrina BertilaccioErich GulbinsCristina ParadisiMario ZorattiGianpietro Carlo SemenzatoLuigi LeanzaLivio TrentinIldikò SzaboPublished in: Journal of experimental & clinical cancer research : CR (2022)
Altogether, by comparing vehicle versus compound effect in different Eμ-TCL1 animals bearing unique clones similarly to CLL patients, we conclude that PAPTP significantly reduced leukemia burden in CLL-relevant districts, even in animals with advanced stage of the disease. Our results thus identify PAPTP as a very promising drug for CLL treatment, even for the chemoresistant forms of the disease.
Keyphrases
- chronic lymphocytic leukemia
- end stage renal disease
- ejection fraction
- chronic kidney disease
- newly diagnosed
- oxidative stress
- prognostic factors
- acute myeloid leukemia
- peritoneal dialysis
- endoplasmic reticulum stress
- genome wide
- computed tomography
- emergency department
- gene expression
- magnetic resonance
- peripheral blood
- cell cycle arrest
- image quality
- contrast enhanced