Preclinical evaluation of cancer immune therapy using patient-derived tumor antigen-specific T cells in a novel xenograft platform.

Gautam N ShenoyChristopher J GreeneMaulasri BhattaMiren L BarojaJenni L LoyallSathy V Balu-IyerRaymond J KelleherBeatriz M CarrenoGerald P LinetteLeonard D ShultzRichard B Bankert

Published in: Clinical & translational immunology (2021)

Together, these results validate the X-mouse model and establish its potential to preclinically evaluate the therapeutic efficacy of immune-based therapies.

Keyphrases

mouse model
papillary thyroid
cell therapy
high throughput
stem cells
childhood cancer
single cell
replacement therapy