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Thromboxane promotes smooth muscle phenotype commitment but not remodeling of hypoxic neonatal pulmonary artery.
Fabiana Postolow
Jena Fediuk
Nora Nolette
Martha Hinton
Shyamala Dakshinamurti
Published in:
Fibrogenesis & tissue repair (2015)
We conclude that thromboxane does not initiate phenotypic dedifferentiation and proliferative activation in PPHN PA. Exposure to thromboxane triggers cell cycle exit and myocyte commitment to contractile phenotype.
Keyphrases
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smooth muscle
cell cycle
pulmonary artery
coronary artery
pulmonary hypertension
pulmonary arterial hypertension
cell proliferation
skeletal muscle