Morphology and Biochemistry of Ovulation.
Sebastião Freitas de MedeirosBruna Barcelo BarbosaMatheus Antônio Souto de MedeirosMárcia Marly Winck YamamotoPublished in: Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia (2021)
The process of ovulation involves multiple and iterrelated genetic, biochemical, and morphological events: cessation of the proliferation of granulosa cells, resumption of oocyte meiosis, expansion of cumulus cell-oocyte complexes, digestion of the follicle wall, and extrusion of the metaphase-II oocyte. The present narrative review examines these interrelated steps in detail. The combined or isolated roles of the follicle-stimulating hormone (FSH) and luteinizing hormone (LH) are highlighted. Genes indiced by the FSH genes are relevant in the cumulus expansion, and LH-induced genes are critical for the resumption of meiosis and digestion of the follicle wall. A non-human model for follicle-wall digestion and oocyte release was provided.
Keyphrases
- genome wide
- polycystic ovary syndrome
- bioinformatics analysis
- genome wide identification
- induced apoptosis
- endothelial cells
- anaerobic digestion
- dna methylation
- signaling pathway
- single cell
- stem cells
- cell cycle arrest
- genome wide analysis
- type diabetes
- copy number
- gene expression
- cell therapy
- diabetic rats
- bone marrow
- metabolic syndrome
- drug induced
- mesenchymal stem cells
- endoplasmic reticulum stress
- pi k akt