ZNF507 affects TGF-β signaling via TGFBR1 and MAP3K8 activation in the progression of prostate cancer to an aggressive state.

Wookbong KwonSeong-Kyoon ChoiDaehwan KimHyeon-Gyeom KimJin-Kyu ParkJee Eun HanGil-Jae ChoSungho YunWookyung YuSe-Hyeon HanYun-Sok HaJun Nyung LeeTae Gyun KwonDong-Hyung ChoJun-Koo YiMyoung Ok KimZae Young RyooSong Park

Published in: Journal of experimental & clinical cancer research : CR (2021)

Our findings suggest that ZNF507 is a novel key regulator of TGF-β signaling in the progression of malignant PC and could be a promising target for studying the development of advanced metastatic PCs.

Keyphrases

prostate cancer
transforming growth factor
small cell lung cancer
squamous cell carcinoma
radical prostatectomy
transcription factor
epithelial mesenchymal transition
signaling pathway