Acute IL-1RA treatment suppresses the peripheral and central inflammatory response to spinal cord injury.
Abi G YatesTrisha JogiaEllen R GillespieYvonne CouchMarc J RuitenbergDaniel Clive AnthonyPublished in: Journal of neuroinflammation (2021)
Our data indicate that peripheral administration of IL-1RA can attenuate the APR which in turn reduces immune cell infiltration at the spinal cord lesion site. We propose IL-1RA treatment as a viable therapeutic strategy to minimise the harmful effects of SCI-induced inflammation.
Keyphrases
- spinal cord injury
- spinal cord
- inflammatory response
- rheumatoid arthritis
- oxidative stress
- disease activity
- drug induced
- liver failure
- interstitial lung disease
- sensitive detection
- systemic sclerosis
- idiopathic pulmonary fibrosis
- quantum dots
- chemotherapy induced
- endothelial cells
- single molecule
- extracorporeal membrane oxygenation