Differences in muscle energy metabolism and metabolic flexibility between sarcopenic and nonsarcopenic older adults.
Marni E ShoemakerSuzette L PereiraVikkie A MustadZachary M GillenBrianna D McKayJose M Lopez-PedrosaRicardo RuedaJoel T CramerPublished in: Journal of cachexia, sarcopenia and muscle (2022)
The data show differences in skeletal muscle energy metabolism and substrate utilization between S and NS at rest, transitioning from fasted to fed state, and during exercise. Compared with NS, S displayed a diminished ability to adapt fuel utilization in response to feeding and exercise, reflecting metabolic inflexibility. Impaired metabolic flexibility could be a mechanism underlying the losses of strength and physical function accompanying sarcopenia.