Therapeutic Importance of Kaempferol in the Treatment of Cancer through the Modulation of Cell Signalling Pathways.
Malak Yahia QattanMohammad Idreesh KhanShudayyed Hasham AlharbiAmit Kumar VermaFatimah A Al-SaeedAlduwish Manal AbduallahAzza A Al AreefyPublished in: Molecules (Basel, Switzerland) (2022)
Plant-derived flavonoids are considered natural nontoxic chemo-preventers and have been widely studied for cancer treatment in recent decades. Mostly all flavonoid compounds show significant anti-inflammatory, anticancer and antioxidant properties. Kaempferol (Kmp) is a well-studied compound and exhibits remarkable anticancer and antioxidant potential. Kmp can regulate various cancer-related processes and activities such as cell cycle, oxidative stress, apoptosis, proliferation, metastasis, and angiogenesis. The anti-cancer properties of Kmp primarily occur via modulation of apoptosis, MAPK/ERK1/2, P13K/Akt/mTOR, vascular endothelial growth factor (VEGF) signalling pathways. The anti-cancer property of Kmp has been recognized in several in-vivo and in-vitro studies which also includes numerous cell lines and animal models. This flavonoid possesses toxic activities against only cancer cells and have restricted toxicity on healthy cells. In this review, we present extensive research investigations about the therapeutic potential of Kmp in the management of different types of cancers. The anti-cancer properties of Kmp are discussed by concentration on its capability to target molecular-signalling pathway such as VEGF, STAT, p53, NF-κB and PI3K-AKT signalling pathways. The anti-cancer property of Kmf has gained a lot of attention, but the accurate action mechanism remains unclear. However, this natural compound has a great pharmacological capability and is now considered to be an alternative cancer treatment.
Keyphrases
- pi k akt
- cell cycle arrest
- vascular endothelial growth factor
- signaling pathway
- cell proliferation
- oxidative stress
- cell cycle
- induced apoptosis
- anti inflammatory
- endothelial cells
- diabetic rats
- ischemia reperfusion injury
- dna damage
- cell death
- single cell
- combination therapy
- endoplasmic reticulum stress
- stem cells
- cell therapy
- working memory
- radiation therapy
- papillary thyroid
- squamous cell carcinoma
- photodynamic therapy
- mesenchymal stem cells
- toll like receptor