CDKN2A/B co-deletion is associated with increased risk of local and distant intracranial recurrence after surgical resection of brain metastases.
Ramin A MorshedMinh P NguyenDaniel D CumminsSatvir SaggiJacob S YoungAlexander F HaddadEzequiel GoldschmidtEdward F ChangMichael W McDermottMitchel S BergerPhilip V TheodosopoulosShawn L Hervey-JumperMariza DarasManish K AghiPublished in: Neuro-oncology advances (2023)
co-deletion detected in BMs is associated with increased CNS recurrence after surgical resection. Additional work is needed to determine whether more aggressive treatment in patients with this mutation may improve outcomes.