Preclinical investigation in FAAH inhibition as a neuroprotective therapy for frontotemporal dementia using TDP-43 transgenic male mice.
Irene Santos-GarcíaCarmen Rodríguez-CuetoPatricia VillegasFabiana PiscitelliAnna LauritanoChe-Kun J ShenVincenzo Di MarzoJavier Fernández-RuizEva de LagoPublished in: Journal of neuroinflammation (2023)
Our data confirmed the potential of elevating the endocannabinoid tone as a therapy against TDP-43-induced neuropathology in FTD, limiting glial reactivity, preserving neuronal integrity and improving cognitive, emotional and social deficits.
Keyphrases
- amyotrophic lateral sclerosis
- cerebral ischemia
- diabetic rats
- high glucose
- mental health
- healthcare
- traumatic brain injury
- electronic health record
- cell therapy
- big data
- drug induced
- neuropathic pain
- oxidative stress
- endothelial cells
- human health
- subarachnoid hemorrhage
- blood brain barrier
- brain injury
- data analysis
- mesenchymal stem cells