Complete blood cell count-derived ratios can be useful biomarkers for neurological diseases.
Fabiana NovellinoAnnalidia DonatoNatalia MalaraJosé L M MadrigalGiuseppe DonatoPublished in: International journal of immunopathology and pharmacology (2022)
Complete blood cell count-derived parameters such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) have recently shown to be highly sensitive biomarkers. Their usefulness has been proven as prognostic factors in several cancers, in the stratification of mortality in major cardiac events, as predictors and markers of infectious or inflammatory pathologies, and in many other conditions. Surprisingly, the study of these biomarkers in neurological diseases is somewhat limited. This paper aims to take stock of the data present in the literature regarding the complete blood cell count-derived ratios in this group of pathologies and to formulate a hypothesis, based on the most recent data concerning innate and acquired immunity, on which diseases of the nervous system could benefit in diagnostic and prognostic terms from the in-depth study of these new biomarkers.
Keyphrases
- peripheral blood
- prognostic factors
- single cell
- cell therapy
- systematic review
- immune response
- big data
- oxidative stress
- heart failure
- cardiovascular events
- machine learning
- brain injury
- young adults
- coronary artery disease
- blood brain barrier
- subarachnoid hemorrhage
- cerebral ischemia
- single molecule
- molecularly imprinted